The A/14 motorway (Bologna - Taranto) serves it with two exits: Ascoli Piceno- S. Benedetto for the southern part and Grottammare for the northern part.

From Rome it is convenient to take the A/24 (Roma - L'Aquila) to the end, continue towards Giulianova and then take the A/14.

Those coming from Florence can exit the Autostrada del Sole at the Val di Chiana tollbooth and follow an itinerary of superhighways: Perugina - Foligno, Muccia, Macerata - Civitanova, S. Benedetto. Alternatively, you can exit at the Orte tollbooth and, still using the highways, retrace this itinerary touching Terni, Foligno, the Sibillini and Ancona.

The railway station provides frequent connections with other railway nodes on the lines that affect the region: the Milan - Bologna - Ancona - Lecce and the Rome - Falconara - Ancona.

San Benedetto can be reached through:

the Ancona Falconara "Raffaello Sanzio" airport which is connected to Milan, Rome, Palermo, London, Munich and some Eastern European capitals

Pescara airport also connected with some Italian and European cities

The port of Ancona is a stopover for shipping lines to and from Croatia, Greece, Turkey, Cyprus and Israel.

Many bus lines connect the city with the major centers of Italy: Rome, for example, can be reached by bus in just over three hours.

From and to the Capital it is possible to use the service of two bus lines: Roma Marche lines s.p.a. and Start spa.